ea0016p515 | Obesity | ECE2008
Isken Frank
, Pfeiffer Andreas FH
, Nogueiras Ruben
, Osterhoff Martin A
, Ristow Michael
, Thorens Bernard
, Tschop Matthias H
, Weickert Martin O
Objectives: Premature estrogen deficiency and menopause are associated with increases in body weight and fat mass. Ovariectomized (OVX) mice also show reduced locomotor activity. Because glucose-dependent-insulinotropic-polypeptide (GIP) is known to play an important role both in fat metabolism and locomotor activity, we hypothesized that effects of estrogen on the regulation of body weight, fat mass and spontaneous physical activity could be mediated in part by GIP signaling....